Altered fractional amplitude of low-frequency fluctuation in women with premenstrual syndrome via acupuncture at Sanyinjiao (SP6)

Abstract Background Premenstrual syndrome (PMS) is a prevalent gynecological disease and significantly associated with abnormal neural activity. Acupuncture an effective treatment on PMS in clinical practice. However, few studies have been performed to investigate whether acupuncture might modulate the activity patients PMS. Thereby, aim of study was assess alterations brain induced by stimulation patients. Methods Twenty were enrolled this study. All received 6-min resting-state functional magnetic resonance imaging (rs-fMRI) scan before after electro-acupuncturing (EAS) at Sanyinjiao (SP6) acupoint late luteal phase menstrual. Fractional amplitude low-frequency fluctuation (fALFF) method applied examine EAS-related changes Results Compared pre-EAS SP6, increased fALFF value several regions including brainstem, right thalamus, bilateral insula, paracentral lobule, cerebellum, meanwhile, decreased left cuneus, precuneus, inferior temporal cortex. Conclusions Our findings provide evidence support that SP6-related may This partly interpret mechanisms SP6 which used treat clinical. Trial registration : The registered http://www.chictr.org.cn . Clinical Registration Number ChiCTR-OPC-15005918, registry 29/01/2015.